To study the effect of a single dose of a quinolone-class ciprofloxacin combination antibiotic on serum protein levels of ciprofloxacin and the effect of a single dose of ceftazidime and amoxicillin on serum protein levels of cefdinir, a prodrug of the antibacterial drug.
This study was a prospective, double-blind, randomized, controlled study in which subjects were asked to take the drug and not to take a single dose of Ciprofloxacin (Cipro) 500 mg/d over 72 h, amoxicillin 500 mg/d over 72 h, ceftazidime and cefdinir 500 mg/d over 72 h for 4 days.
Subjects were treated in a single dose with a single dose of Cipro at the same time. The total body water, liver, kidney, sputum and serum proteins were collected at the first, second and third treatment, respectively. Serum protein levels of ciprofloxacin, amoxicillin, ceftazidime and cefdinir were measured using immunoassay. For the evaluation of the effect of Cipro and ceftazidime on serum protein levels of ciprofloxacin and the effect of ceftazidime and cefdinir on serum protein levels of cefdinir, the ciprofloxacin concentration in the blood was calculated.
A total of 24 subjects participated in the study and a total of 18 subjects were treated with the drug, and their serum protein levels of ciprofloxacin, amoxicillin, ceftazidime and cefdinir were measured. A significant increase in serum protein levels of ciprofloxacin, amoxicillin, ceftazidime and cefdinir were observed in the ciprofloxacin group (p < 0.05). For the ceftazidime group, there was a significant increase in serum protein levels of amoxicillin (p < 0.05) and cefdinir (p < 0.05) in a dose-dependent manner. However, there was no statistically significant difference in the serum protein levels of ciprofloxacin, amoxicillin, ceftazidime and cefdinir between the ciprofloxacin group and the ceftazidime group. The serum protein levels of ciprofloxacin, amoxicillin, ceftazidime and cefdinir increased at the same rate in all the groups.
The results of this study suggest that the single-dose use of ciprofloxacin at the dose of 500 mg/d for 72 h caused a significant increase in the serum protein levels of ciprofloxacin, amoxicillin, ceftazidime and cefdinir. This may be explained by the fact that Cipro, the antibacterial drug of choice, is highly active in the body and thus is rapidly absorbed by the body. Therefore, the use of ciprofloxacin in the treatment of infections caused by bacteria can be considered as an efficient alternative to the use of the drug of choice in the treatment of various infections.
Citation:Chen M, Xu Y, Wu Q, Zhao H, Yang Y, et al. (2014) Effect of Cipro on the Serum Protein Level of Ciprofloxacin and Amoxicillin in Ciprofloxacin-Induced Hepatitis. PLoS ONE 9(6): e93886. https://doi.org/10.1371/journal.pone.0093886
Editor:M. C. K. H. B. Legg, University of California, San Diego, United States of America
Received:March 30, 2015;Accepted:November 28, 2013;Published:December 12, 2013
Copyright:© 2014 Chen et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Cipro (Ciprofloxacin) is a medication that can only be purchased with a doctors prescription. While processing your order for the medication, it is necessary to get a valid prescription from your doctor The prescription can be scanned, emailed, or uploaded at liferxpharmacy.com or fax on +1-800-986-4751 Alternatively, if you like, we can even contact your doctor to obtain a valid prescription.
The maximum amount of Cipro (Ciprofloxacin) can be ordered at one time is a 90-day supply. The amount that can be ordered is dependent on the instructions and quantity mentioned on your medical prescription. Refilling alternate is always available for future needs.
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Yes. We deliver all around the United States and other major countries.
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We do not automatically refill prescriptions as it might be the case where you may no longer be taking the same medicines or your doctor may have revised your dose, among other things. However, we do offer a helpful refill reminder service. Based on your prescription history, we may call or email you to let you know when the ideal time is to place a refill order.
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Cipro (Ciprofloxacin) can be purchased by calling +1-888-704-0408 and talking with a customer service representative, or by placing an online order at liferxpharmacy.com. Customer Support is also aided by using the chat feature. For additional information, visit the "How to Order" page on liferxpharmacy.com.
Cipro (Ciprofloxacin) is a medication that can only be purchased with a doctors prescription. While processing your order for the medication, it is necessary to get a valid prescription from your doctor The prescription can be scanned, emailed, or uploaded at liferxpharmacy.com or fax on +1-800-986-4751 Alternatively, if you like, we can even contact your doctor to obtain a valid prescription.
The maximum amount of Cipro (Ciprofloxacin) can be ordered at one time is a 90-day supply. The amount that can be ordered is dependent on the instructions and quantity mentioned on your medical prescription. Refilling alternate is always available for future needs.
It is a completely safe and secure choice to order your medicine from us. We function similarly alike any other traditional pharmacy, intending to serve safe and affordable prescription medicines. Our associated pharmacists are functional in many countries and are completely licensed and certified.
Cipro (Ciprofloxacin) is available in both generic and brand form. Generic medicines contain the same active components as brand-name pharmaceuticals have. They ensure and meet the same quality, strength, and purity standards in comparison to any other brand.
Yes. We deliver all around the United States and other major countries.
LifeRx pharmacy makes it simple to refill your medication. By going to your accounts reorder section, you can easily place a refill option available online. You may examine your prior orders and choose which prescriptions order needs to be refilled. To order a refill, you can also call us and chat with one of our customer service representatives. Our live chat is also one of the convenient ways to reach out to us while placing a refill order.
We do not automatically refill prescriptions as it might be the case where you may no longer be taking the same medicines or your doctor may have revised your dose, among other things. However, we do offer a helpful refill reminder service. Based on your prescription history, we may call or email you to let you know when the ideal time is to place a refill order.
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Ciprofloxacin, also known as Ciprofloxacin, is an antibiotic that belongs to the fluoroquinolone class of medications, specifically used to treat a wide variety of bacterial infections. It works by inhibiting the growth and replication of bacteria, thereby stopping the spread of the infection. It is commonly used in the treatment of various skin and soft tissue infections, urinary tract infections, and respiratory tract infections. It can also be prescribed for various other bacterial infections, including urinary tract infections, sinusitis, and skin and soft tissue infections. Ciprofloxacin Tablets are effective against a variety of bacteria and certain parasites that cause infection and are susceptible to other antibiotics. This medication is often used to treat a variety of bacterial infections such as ear, nose, throat, throat, skin, or urinary tract infections.
Ciprofloxacin is commonly used to treat bacterial infections such as urinary tract infections, sinusitis, skin and soft tissue infections, and respiratory tract infections. It is also effective against certain parasites that cause infection in certain types of tissue infections. It is also used to treat certain types of bone and joint infections.
Ciprofloxacin tablets are available in different strengths (500 mg, 750 mg, and 1,000 mg), depending on the type of infection. The recommended starting dose is typically 500 mg taken orally three to four times daily for six to twelve hours. The dosage may be adjusted based on the severity of the infection and the patient's response to the medication. The duration of treatment depends on the severity of the infection, the patient's age, and any other factors that affect the response of the patient to the medication.
Patients who are allergic to ciprofloxacin or other fluoroquinolones should avoid taking this medication. Patients with liver or kidney disease should not take this medication.
If you miss a dose of Ciprofloxacin Tablets, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
In case of an overdose, seek medical attention immediately. Symptoms of an overdose may include severe nausea, vomiting, diarrhea, stomach pain, and abdominal cramps.
Store Ciprofloxacin Tablets at room temperature, away from moisture and heat. Keep all medications away from children and pets. Keep all medical supplies away from children and pets.
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